Follistatin Therapy Shows Large Muscle Gains

One of those relates to Telomeres – the ends of the chromosomes, containing our genetic material. Ageing is said to be caused when the telomeres become too short when they divides into two or more daughter cells. Scientists have proven that longer telomeres in human are correlated with longer life span.

If you’re waiting for science to come up with the solution to slow down the ageing process and increase how long humans live, don’t hold your breath: you could die waiting. Two main approaches seem to be being pursued.

The way on becoming big, with strong muscles can be long and will require greater work in going to a gym. Thus, the researchers can somehow found a simple way and or shortcut in which the muscles can grow excellently by themselves. Scientists have actually succeeded, by means of gene therapy, to increase the lean body mass and the strength of macaque monkeys. The experiment was simple enough, the researchers just injected the gene follistatin (FS344) directly into the monkeys right thigh muscles.

The Follistatin is injected by means of a viral vector that is an Adeno Associated Virus used as a transport for the drug that is injected.

It is a common method called Gene Therapy, and has been used in humans with other drugs.

The study on the monkeys showed no negative side effects.

This therapy is being developed for use in patients with severe muscle dystrophy and other muscle wasting disorders.

It has been shown that follistatin can block myostatin, a molecule that down-regulates muscle growth, but strengthens tendons. Eight weeks after the injection the circumference of the monkeys right thigh muscles, had on average gone up 15 percent compared with the left thigh? A study done on two of the monkeys showed that muscle strength in the right leg was increased by respectively 12 and 36 per cent compared to the untreated leg!

Ostarine which is a SARM(Selective Androgen Receptor Modulator) and is currently in Human clinical trials by GTx Inc. and also another SARM for sale under the codename BMS-564,929 which is being developed by Bristol-Myers Squibb.

The potential for these substances to be abused by athletes has prompted the World Anti-Doping Agency to have a ban on SARMs since 2008.

Clinical trials on humans are due to start in 2011 and Nationwide Children’s Hospital in Ohio has already gained funding for the study. There are a number of studies and clinical trials either underway or planned for treatment of muscle wasting disorders, among some of the more interesting substances are Follistatin as an antagonist to Myostatin.

So far only the substance known as “SARMs S4” (Andarine) has made it to the market, and is being used by a limited number of pro and amateur bodybuilders, it’s anabolic effects are said to be moderate and it has been reported to have some temporary side effects, among which decreased night vision is the more prominent. Because of this, there are now SARMS for sale in the market.

The future of drugs developed for muscle wasting diseases are sure to be of interest for athletes and others wanting to gain the extra advantage.

These drugs will be available through the black market for pro and amateur athletes alike, with unprecedented anabolic effects and close to no negative side effects.

The next 5-10 years will see a plethora of substances come out and some might be good replacements for Anabolic steroids.

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